گروه های منابع آموزشی
چهارشنبه ۰۵ خرداد ۱۳۹۵ - ۱۳:۳۵      بازدید : ۸۸
ایمونولوژی Roles of Chromatin insulators in gene regulation and diseases

Abstract
With advances in genetic science, the dynamic structure of eukaryotic genome is
considered as basis of gene expression regulation. Long-distance communication
between regulatory elements and target promoters is critical and the mechanisms
responsible for this connection are just starting to emerge. Chromatin insulators
are key determinants of proper gene regulation and precise organization of
chromosomal structures. These elements are DNA-protein complexes which can
mediate interactions within and between chromosomes. In doing so, they can bring
close together regulatory sequences located at large distances from each other. In
addition, insulators may be important in remodeling the architecture of chromosomes
in the cell cycle. Here, we review recent data revealing the structure and properties
of these DNA-protein complexes, their global role in regulation of transcription,
and the mechanisms by which misregulation of their function leads to various
human diseases such as cancers and autoimmune diseases.